The etiology of human idiopathic dilated cardiomyopathy (IDC) is yet unclear; it has been observed, however, that some physiological abnormalities involved in the perpetuation of cardiomyopathy may be affected by calcium channel blockers. Cardiovascular indications include hypertension, coronary spasm, angina pectoris, supraventricular dysrhythmias, hypertrophic cardiomyopathy, and pulmonary hypertension. Calcium Antagonists The second major group of drugs used are the calcium antagonists or calcium channel blockers. Some calcium channel blockers … Calcium … Effects of calcium-channel blocking agents on left ventricular diastolic function in hypertrophic cardiomyopathy and in coronary artery disease. The … Calcium channel blockers are becoming increasingly popular in veterinary medicine for the treatment of systemic hypertension, cardiac arrhythmias, and hypertrophic cardiomyopathy. Calcium channel blockers are becoming increasingly popular in veterinary medicine for the treatment of systemic hypertension, cardiac arrhythmias, and hypertrophic cardiomyopathy. Diuretics, which must be used with caution in this disease, are used to decrease fluid accumulation (when present) from the lungs in children with severe hypertrophic cardiomyopathy… Developed in collaboration with the American Association for Thoracic Surgery, … Tokushima T, Utsunomiya T, Ogawa T, Kidoh K, Ohtsubo Y, Ryu T, Yoshida K, Ogata T, Tsuji S, Matsuo S. Basic Res Cardiol. Re: Beta and Calcium Channel Blockers I was on 180mg of Verapamil and 75mg of Toprol XL before my myectomy. Short-term double-blind studies showed that verapamil improved exercise time by 26 +/- 35% (p less than 0.005) compared with placebo, whereas propranolol improved it by 21 +/- 35% (p less than 0.025). These observations have led to exploration of the effects of calcium channel blockers on systolic and diastolic function in patients with hypertrophic cardiomyopathy. Rosing DR, Idänpään-Heikkilä U, Maron BJ, Bonow RO, Epstein SE. NIH 1985 Jul;17 Suppl 2:59-68. doi: 10.1016/0022-2828(85)90009-4. It had no significant effect on heart rate, mean pulmonary artery wedge pressure, left ventricular (LV) end-diastolic pressure or cardiac output; however, LV outflow gradient in the basal state decreased from 62 +/- 34 to 29 +/- 34 mm Hg (p less than 0.05). Beta-blockers and calcium channel blocker blockers are two classes of medications that may be prescribed. These findings demonstrate a decrease in LV outflow tract obstruction. A decrease in ventricular septal thickness of 1.5 +/- 2.6 mm was also found in 32 patients studied after 39 +/- 8 months of verapamil therapy. Please enable it to take advantage of the complete set of features! Beta blockers decrease heart rate, reducing the heart’s workload. A retrospective cohort study of patients with HC with coexisting hypertension … All patients had clinical, non-invasive and cardiac catheterization evaluation at the time of entry into the study. Clipboard, Search History, and several other advanced features are temporarily unavailable. Beta Blockers. These drugs have been shown to increase the cardiac … Preclinical evidence suggests calcium channel blockers (CCB) may have beneficial molecular … Mechanism of Action. 1985 Jan 25;55(3):69B-80B. Effects of beta-blockers (propranolol, penbutolol) and calcium antagonists (nifedipine, verapamil, diltiazem) were studied in 73 patients with hypertrophic cardiomyopathy (HC). Nitrates, ACEIs, nifedipine type-calcium channel blockers and positive inotropes are contraindicated in the treatment of this disease as the increase cardiac output and worsen the features of ventricular outflow obstruction. 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